Animal & Dairy Science: Personnel
Clifton A. Baile
Clifton A. Baile B.S., Central Missouri State College Edgar L. Rhodes Center for ADS |
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Description of Research Interests
Our laboratory has broad interests in the molecular basis of energy balance regulation and growth. Our research includes various aspects of the control of feeding behavior and energy balance regulation by the central nervous system and adipose tissue. The roles of leptin and growth hormone in these functions are of particular interest. We are also investigating the roles of natural compounds in adipogenesis, lipolysis and adipocyte apoptosis. Biotechnology tools, including the development of transgenic animals and a variety of genomic and proteomic technologies, are utilized to study the molecular basis of these systems of animal physiology.
We have coordinated the Georgia Research Alliance's program in Agricultural Biotechnology at the University of Georgia. This program has dual goals of conducting leading-edge research and seeding start-up companies to commercialize animal and plant biotechnology in Georgia. State of the art equipment, in conjunction with cutting-edge technologies such as genomics, bioinformatics, vector construction, both high through-put screening and genotyping, and transgenesis are available.
Selected Recent Publications
Qian, H., G. J. Hausman, M. M. Compton, M. J. Azain, D. L. Hartzell, and C. A. Baile. Leptin Regulation of Peroxisome Proliferator-Activated Receptor, Tumor Necrosis Factor and Uncoupling Protein-2 Expression in Adipose Tissues. Biochemical and Biophysical Research Communications. 246 (3):660-667. 1998.
Qian, H., M. J. Azain, D. L. Hartzell, and C. A. Baile. Increased Leptin Resistance as Rats Grow to Maturity. Proceedings of the Society for Experimental Biology and Medicine. 219(2):160-165. 1998.
Wang, T., D. L. Hartzell, W. P. Flatt, R. J. Martin, and C. A. Baile. Responses of Lean and Obese Zucker Rats to Centrally Administered Leptin. Physiology and Behavior 65:333-341, 1998.
Qian, H., G. J. Hausman, M. M. Compton, M. J. Azain, D. L Hartzell, and C. A. Baile. Down-regulation of CCAAT/enhancer binding proteins in adipose tissue by intracerebroventricular leptin in rats. BBA 1442:245-55. 1998.
Houseknecht, K. L., C. A. Baile, R. L.Matteri, and M. E Spurlock . The Biology of Leptin: A Review. J. Anim. Sci. 76:1405-20. 1998.
Chen, X-L., D.L. Hartzell, R.A. McGraw, G.J. Hausman, R.G. Dean, K. Lee, and C.A. Baile. Analysis of a 762-bp proximal leptin promoter to drive and control regulation of transgene expression of growth hormone receptor in mice. Biochemical and Biophysical Research Communications. 262: 187-192, 1999.
Stice, S.L., J. Gibbons, S.J. Rzucidlo, and C.A. Baile. Improvements in nuclear transfer procedures will increase commercial utilization of animal cloning. Asian-Australian Journal of Animal Science. Asian-Australian Journal of Animal Science, 13:856-860
Lee, K., C.R. Barb, R.R. Kraeling, R.T. Riley, R.A. McGraw, R.G. Dean, C.A. Baile. Expression of beta-galactosidase and pig leptin gene in vitro by recombinant adenovirus. Animal Biotechnology, 10(1-2): 37-48, 1999.
Kim, H.S., D.B. Hausman, M.M. Compton, R.G. Dean, R.J. Martin, G.J. Hausman, D.L. Hartzell, and C.A. Baile. Induction of apoptosis by all-trans-retinoic acid and C2-ceramide treatment in rat stromal-vascular (S-V) cultures. BBRC, 270: 76-80, 2000.
Baile , C.A. , M.A. Della-Fera, R.J. Martin. Regulation of metabolism and body fat mass by leptin. Annual Review of Nutrition 20:105-127, 2000.
Miner, J.L. , C.A. Cederberg, M.K. Nielsen, X-L. Chen, and C.A. Baile. Conjugated linoleic acid (CLA), body fat, and apoptosis. Obes Res 9(2):129-134, 2001.
Kim, H.S., L. Liang, R.G. Dean, D.B. Hausman, D.L. Hartzell, and C. A. Baile. Inhibition of preadipocyte differentiation by myostatin treatment in 3T3-L1 cultures. BBRC, 281:902-906, 2001.
Gullicksen, P.S., W.P. Flatt, R.G. Dean, D.L. Hartzell, and C.A. Baile. Energy metabolism and expression of uncoupling proteins 1, 2 and 3 after twenty-one days of recovery from mouse leptin ICV in rats. Physiology and Behavior, 2002
Arnold , H.B., M.A. Della-Fera, and C.A. Baile. Review of myostatin history, physiology and applications. LifeXY 2001: 1014-1022.
Qian, H., D. B. Hausman, M. M. Compton, R. J. Martin, M. A. Della-Fera, D. L. Hartzell, and C. A. Baile. TNF alpha induces and insulin inhibits caspase 3-dependent adipocyte apoptosis. BBRC, 284(5):1176-83, 2001.
Della-Fera, M. A., H. Qian, and C. A. Baile. Adipocyte apoptosis in regulation of body fat mass by leptin. Diabetes, Obesity and Metabolism, 3:200-310,2001.
Lin, J., H. B. Arnold, M. A. Della-Fera, M. A. Azain, D. L. Hartzell, and C. A. Baile. Myostatin knockout in mice increases myogenesis and decreases adipogenesis. Biochem Biophys Res Commun 2002, Mar. 1; 291(3): 701-706.
Gullicksen, P.S., W.P. Flatt, R.G. Dean, D.L. Hartzell, and C.A. Baile. Energy metabolism and expression of uncoupling proteins 1, 2 and 3 after twenty-one days of recovery from mouse leptin ICV in rats. Physiology and Behavior, 75:473-482, 2002.
Hargrave KM, Li C, Meyer BJ, et al. Adipose depletion and apoptosis induced by trans-10, cis-12 conjugated linoleic Acid in mice. Obes Res. Dec 2002;10(12):1284-1290.
Gullicksen PS, Hausman DB, Dean RG, Hartzell DL, Baile CA. Adipose tissue cellularity and apoptosis after intracerebroventricular injections of leptin and 21 days of recovery in rats. International Journal of Obesity. 2003;27(3):302-312.
Gullicksen PS, Dean RG, Baile CA. Detection of DNA Fragmentation and Apoptotic Proteins, and Quantification of Uncoupling Protein Expression by Real-Time RT-PCR in Adipose Tissue. J Biochem Biophys Methods. 2003;in press.
Gullicksen PS, Della-Fera MA, Baile CA. Leptin-Induced Adipose Apoptosis: Implications for Body Weight Regulation. Apoptosis. 2003;8:327-335.
Della-Fera M.A., C. Li and CA Baile. Resistance to IP leptin-induced adipose apoptosis caused by high fat diet in mice. Biochem. Biophys. Res. Commun. 303:1053-1057 2003.
Choi, Y. H., C. L. Li, K. Page, A. Westby, M. A. Della-Fera, J. Lin, D. L. Hartzell, and CA Baile. Melanocortin receptors mediate leptin effects on feeding and body weight, but not adipose apoptosis. Physiology and Behavior. 79:795-801, 2003.
Duff, Emily and Clifton A. Baile . Ciliary Neurotrophic Factor – A Role in Obesity? Nutrition Reviews 61:423-426, 2003.
Page, KA., DL. Hartzell, CL Li, AL. Westby , MA Della-Fera, MJ. Azain, TD. Pringle and CA Baile. Effects of b -adrenergic Receptor Agonists on Adipose Tissue Growth and Apoptosis in Mice. Domestic Animal Endocrinology. In press.
Lin, J., YH Choi, DL. Hartzell, CL Li, MA Della-Fera and CA Baile. CNS melanocortin and leptin effects on stearoyl-CoA desaturase 1 and resistin expression. Biochemical and Biophysical Research Communications 311:324-328, 2003.
Duff, E., C.-L. Li, D.L. Hartzell, Y.-H. Choi, M.A. Della Fera, and CA Baile, Ciliary Neurotrophic Factor Injected ICV Induces Adipose Tissue Apoptosis in Rats. Apoptosis 9:629-634, 2004.
Hargrave, Kimberly M., Brett J. Meyer, Changlong Li , Michael J. Azain, Clifton A. Baile , Jess L. Miner. Influence of Conjugated Linoleic Acid and Fat Source on Body Fat and Apoptosis in Mice. Obesity Research 12, 2004.
Lin, Ji, Karen Page , Mary Anne Della-Fera and Clifton A. Baile . Evaluation of Adipocyte Apoptosis by Laser Scanning Cytometry. International Journal of Obesity. In press.
Lin, Ji, Yang-Ho Choi , Diane L. Hartzell , ChangLong Li , Mary Anne Della-Fera and Clifton A. Baile . CNS melanocortin and leptin effects on stearoyl-CoA desaturase 1 and resistin expression. Biochemical and Biophysical Research Communications 311:324-328, 2003.
Choi, Yang-Ho, Mary Anne Della-Fera , ChangLong Li, Diane L. Hartzell , Dianne E. Little, Michael J. Kuhar and Clifton A. Baile. CART peptide: Central mediator of leptin-induced adipose tissue apoptosis? Regulatory Peptides 121: 155-162, 2004.